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Oxatomide plasma levels in man during chronic dosing.

B H Davies, K Rocchiccioli

    Pharmatherapeutica
    |January 1, 1983
    PubMed
    Summary
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    This study measured oxatomide plasma levels in 8 subjects over 22 days. Steady-state levels were reached by day six, indicating consistent drug accumulation during chronic dosing.

    Area of Science:

    • Pharmacokinetics
    • Drug Metabolism and Transport

    Background:

    • Oxatomide is an antihistamine medication.
    • Understanding its pharmacokinetic profile is crucial for effective therapeutic use.

    Purpose of the Study:

    • To determine steady-state plasma concentrations of oxatomide.
    • To evaluate the time course of oxatomide levels during chronic oral administration.

    Main Methods:

    • A radioimmunoassay technique was employed for plasma oxatomide quantification.
    • Eight healthy subjects received 30 mg of oxatomide twice daily for 22 days.

    Main Results:

    • Mean steady-state plasma oxatomide levels reached 20-30 ng/ml just before the next dose.
    • Peak plasma levels of approximately 40 ng/ml were observed 4 hours post-dose.

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  • These steady-state levels were achieved by the sixth day of treatment.

    • Conclusions:

    • Chronic dosing of oxatomide at 30 mg twice daily leads to predictable steady-state plasma levels.
    • The pharmacokinetic data suggest consistent absorption and accumulation of oxatomide over time.