[Na+, K+ -ATPase inactivation as a trigger coupling factor of mediator depolarization and secretion]

The paper deals with an analysis of ouabain-induced processes: a decrease in transmembrane potential of neurone, an increase in the intensity of passive Na+, K+ and Ca2+ transport, secretion of different mediators by nerve endings. A hypothesis on inactivation of Na+, K+-ATPase as a trigger coupling factor of depolarization and secretion of mediators (and hormones) is discussed. According to this hypothesis inhibition of the Na, K-pump "work" may induce an additional opening of ion-selective canals, cause Ca2+ outflow from synaptic mitochondria to synaptoplasm due to intracellular accumulation of Na+, promote penetration of Ca2+ into a cell through the Ca2+ and Na+ metabolism.