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Hormonal effects of beta-receptor blockade during exercise.

G Johansson, M Uusitupa, M Härkönen

    Acta Endocrinologica
    |September 1, 1983
    PubMed
    Summary

    Beta-receptor blocking agents like metoprolol and propranolol affect hormonal responses to exercise. Non-selective propranolol showed more distinct effects on hormones compared to placebo and selective metoprolol.

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    Area of Science:

    • Endocrinology
    • Exercise Physiology
    • Pharmacology

    Background:

    • Beta-receptor blocking agents are widely used for cardiovascular conditions.
    • Their impact on hormonal responses during physical activity requires further elucidation.
    • Understanding these effects is crucial for managing patients undergoing exercise and medication.

    Purpose of the Study:

    • To compare the effects of a beta 1-selective (metoprolol) and a non-selective (propranolol) beta-receptor blocking agent on hormonal responses to exercise.
    • To assess the influence of these agents versus placebo on plasma prolactin, testosterone, LH, and FSH levels during and after exercise.

    Main Methods:

    • A double-blind, cross-over study involving 7 healthy male volunteers.
    • Participants underwent a 30-minute bicycle ergometer test under three conditions: placebo, metoprolol (150 mg/day), and propranolol (120 mg/day).
    • Hormonal levels (prolactin, testosterone, LH, FSH) were measured before, during, and after exercise.

    Main Results:

    • Plasma prolactin levels decreased with exercise but were consistently higher with both beta-blockers compared to placebo.
    • Plasma testosterone levels were unaffected by exercise but remained higher during propranolol treatment than with placebo or metoprolol.
    • Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were not significantly altered by exercise or beta-blockade.

    Conclusions:

    • Beta-receptor blocking agents interfere with physiological endocrine functions during exercise.
    • Non-selective agents, such as propranolol, may exert more pronounced effects on hormonal responses compared to selective agents like metoprolol.
    • These findings highlight the importance of considering medication type when evaluating hormonal changes in physically active individuals.

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