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Pregnancy and Takayasu's arteritis.

V C Wong, R Y Wang, T F Tse

    The American Journal of Medicine
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Pregnancies in women with Takayasu arteritis (TA) before diagnosis were uneventful. After TA diagnosis, pregnancies carried risks like hypertension and intrauterine growth retardation, but maternal and infant outcomes were generally favorable with proper management.

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    Area of Science:

    • Cardiology
    • Rheumatology
    • Obstetrics

    Background:

    • Takayasu arteritis is a rare, chronic inflammatory disease affecting large arteries, primarily the aorta and its branches.
    • Pregnancy in women with Takayasu arteritis presents unique challenges due to potential cardiovascular complications and disease activity.
    • Limited data exists on pregnancy outcomes in patients with Takayasu arteritis, necessitating further investigation.

    Purpose of the Study:

    • To evaluate pregnancy outcomes in women with Takayasu arteritis.
    • To identify risk factors and potential complications associated with pregnancy in Takayasu arteritis patients.
    • To assess maternal and fetal well-being during and after pregnancy in this cohort.

    Main Methods:

    • Retrospective analysis of 30 pregnancies in 13 patients with Takayasu arteritis between 1970 and 1982.

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  • Comparison of pregnancy outcomes before and after the clinical manifestation of Takayasu arteritis.
  • Assessment of obstetric complications, maternal mortality, and fetal outcomes, including asphyxia and congenital abnormalities.
  • Development and application of a prognostic score to predict intrauterine growth retardation.

    • Main Results:

    • Eleven pregnancies before Takayasu arteritis diagnosis were uneventful.
    • Nineteen pregnancies after Takayasu arteritis diagnosis resulted in 4 abortions, 4 cesarean sections, and 11 vaginal deliveries.
    • Hypertension was the primary obstetric complication; no direct maternal deaths related to pregnancy occurred.
    • All 15 evaluated infants were born without asphyxia or congenital abnormalities.
    • A prognostic score, considering therapy timing, hypertension severity, and arterial involvement, predicted intrauterine growth retardation in nine infants.

    Conclusions:

    • Pregnancy outcomes in Takayasu arteritis are significantly influenced by disease manifestation and activity.
    • While risks such as hypertension and intrauterine growth retardation exist post-diagnosis, maternal and fetal outcomes can be favorable.
    • A predictive prognostic score aids in identifying infants at risk for intrauterine growth retardation, enabling timely intervention.