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Hepatic function in ankylosing spondylitis.

A C Robinson, M Teeling, E B Casey

    Annals of the Rheumatic Diseases
    |October 1, 1983
    PubMed
    Summary
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    Elevated alkaline phosphatase and gamma glutamyl transpeptidase (GGTP) levels were observed in ankylosing spondylitis (AS) patients compared to controls. These enzyme elevations may help assess disease activity in AS.

    Area of Science:

    • Biochemistry
    • Rheumatology
    • Clinical Chemistry

    Background:

    • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
    • Liver enzyme abnormalities can occur in various systemic inflammatory conditions.
    • Alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) are key liver enzymes with diagnostic relevance.

    Purpose of the Study:

    • To investigate the prevalence and significance of elevated alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) in patients with ankylosing spondylitis (AS).
    • To determine if these enzyme elevations correlate with disease status in AS.

    Main Methods:

    • A comparative study involving 35 patients diagnosed with ankylosing spondylitis (AS).
    • A control group of 35 age- and sex-matched healthy individuals.

    Related Experiment Videos

  • Measurement of serum alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) levels in all participants.

    • Main Results:

    • Significantly higher values for alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) were found in the AS patient group compared to the control group.
    • A higher prevalence of elevated ALP and GGTP levels was observed in patients with ankylosing spondylitis.
    • The abnormal enzyme levels are suggested to represent a non-specific inflammatory response.

    Conclusions:

    • Elevated alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) are more common in patients with ankylosing spondylitis (AS).
    • These enzyme elevations may serve as indicators of disease activity or inflammation in AS patients.
    • Further research could explore the utility of ALP and GGTP in monitoring AS progression and treatment response.