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Related Experiment Videos

Extrapyramidal disorders: a possible underlying mechanism.

F S Messiha

    Brain Research Bulletin
    |August 1, 1983
    PubMed
    Summary
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    Certain drugs causing extrapyramidal symptoms affect alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) enzyme activity. This may explain alcohol

    Area of Science:

    • Neuropharmacology
    • Biochemistry

    Background:

    • Extrapyramidal disorders are linked to drugs affecting biogenic amine metabolism.
    • Alcohol consumption can exacerbate extrapyramidal symptoms during pharmacotherapy.

    Purpose of the Study:

    • To investigate the interrelationship between drugs inducing extrapyramidal disorders and specific dehydrogenase enzymes.
    • To propose a hypothesis for the mechanism underlying this interaction and alcohol's role.

    Main Methods:

    • In vivo and in vitro studies were conducted.
    • Examined the effect of drugs on rat liver alcohol dehydrogenase (L-ADH) and aldehyde dehydrogenase (L-ALDH).
    • Investigated biogenic amine metabolites as substrates or inducers of L-ADH.

    Main Results:

    Related Experiment Videos

    • Biogenic amine metabolites acted as substrates for or induced L-ADH.
    • Drugs used for tardive dyskinesia also induced L-ADH, potentially enhancing biogenic amine metabolism.
    • Drugs causing extrapyramidal symptoms inhibited L-ALDH, possibly leading to toxic condensation products.

    Conclusions:

    • A potential mechanism involves the balance between reductive and oxidative metabolism of biogenic amines.
    • Drug-induced alterations in dehydrogenase activity may contribute to extrapyramidal disorders.
    • This interaction could explain alcohol's role in worsening symptoms during certain drug treatments.