[Pathogenesis of embolotoxic reactions]

Own investigations concerning the principal mechanisms of Hoigné's syndrome demonstrated that the phenomenology of embolotoxic reactions depends in certain pre-conditions on high pressure during a rapid injection with the result of penetration of the drug into the blood stream. The occurrence of the syndrome and its symptomatology depend on the size of the crystals or lipid droplets that enter the blood stream, on the solubility of the crystals in the body, on the toxicity of the components of a particular drug and on the volume of the injected drug that enters the blood vessels. For the reasons mentioned above the symptomatology of the syndrome is variable and depends on the type of medicament applied.