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Does the autonomic nervous system regulate whole-body lymph flow?

G G Power, R A Brace

    The American Journal of Physiology
    |November 1, 1983
    PubMed
    Summary

    The autonomic nervous system does not significantly impact whole-body lymph flow. Studies show lymph flow responses to fluid shifts and hemorrhage remain unchanged with or without autonomic nervous system activity.

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    Area of Science:

    • Physiology
    • Cardiovascular System
    • Lymphatic System

    Background:

    • The autonomic nervous system regulates many physiological processes, including cardiovascular function and fluid balance.
    • Its role in modulating whole-body lymph flow, a critical component of fluid homeostasis, remains incompletely understood.

    Purpose of the Study:

    • To investigate the influence of the autonomic nervous system on whole-body lymph flow dynamics.
    • To determine if autonomic blockade alters lymph flow responses to fluid infusions and hemorrhage.

    Main Methods:

    • Whole-body lymph flow was measured in pentobarbital-anesthetized dogs before and after ganglionic blockade with hexamethonium.
    • Lymph and plasma protein concentrations, hemodynamic parameters, and hematocrit were monitored.
    • Responses to serial infusions of saline, Ringer's lactate, and Dextran 70, followed by hemorrhage and reinfusion, were assessed.

    Main Results:

    • Ganglionic blockade reduced arterial pressure and heart rate but did not affect baseline lymph flow rate.
    • Autonomic blockade did not alter the magnitude, timing, or decay of lymph flow responses to fluid infusions or hemorrhage.
    • Absolute lymph flow rates during these interventions were comparable between intact and ganglion-blocked states.

    Conclusions:

    • The autonomic nervous system appears to play a minimal role in regulating whole-body lymph flow.
    • Existing hypotheses suggesting a significant contribution of the autonomic nervous system to lymph flow regulation are not supported by these findings.

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