Related Experiment Videos
[Comparative evaluation of the therapeutic effect of various classes of beta-blockaders in patients with
Insights
Different antihypertensive drugs like propranolol, tenormine, and trandate show varied effects on hemodynamics and myocardial performance in hypertensive patients. Long-term use may lead to myocardial hypertrophy regression, influenced by hemodynamic and neurohumoral factors.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Hypertension management requires understanding drug-specific hemodynamic and myocardial effects.
- Various beta-blockers and combined alpha- and beta-blockers are used to treat hypertension.
Purpose of the Study:
- To compare the hemodynamic and myocardial performance changes induced by different antihypertensive medications.
- To investigate the mechanisms of hypotensive action and their impact on cardiac function.
Main Methods:
- A study involving 215 hypertensive patients treated with obsidan (propranolol), corgard, tenormine, and trandate.
- Assessment of hemodynamic parameters, venous blood return, myocardial contractility, and myocardial mass.
Main Results:
- Obsidan and corgard were effective in moderate hypertension with hypersympathicotonia.
- Tenormine and trandate demonstrated significant hypotensive effects by reducing vascular tone.
- Myocardial contractility decreased with obsidan, while trandate showed no change; myocardial hypertrophy regression was observed with tenormine and trandate.
Conclusions:
- Antihypertensive drugs exhibit distinct hemodynamic profiles and impact myocardial performance differently.
- Myocardial hypertrophy regression is linked to both hemodynamic adjustments and neurohumoral influences.
Abstract:
A complex study of changes of hemodynamics and myocardial performance was conducted while treating 215 hypertensive patients with obsidan (propranolol), corgard, a cardioselective beta-blocker tenormine and alpha- and beta-blocker trandate. Different hypotensive efficiency and varying hemodynamic mechanisms of its action were found. Obsidan and corgard were mainly efficient in moderate hypertension and marked hypersympathicotonia. Tenormine and trandate produce the most marked hypotensive effect (due to reduction in the vascular tone). The signs of increase in venous blood return to the heart during trandate and obsidan therapy and decrease in venous return after long-term tenormine therapy were established. Myocardial contractility indices decreased after obsidan therapy to the more extent than after corgard and tenormine, and they did not change after trandate. The possibility of myocardial hypertrophy regression was shown (especially in the long-term treatment with tenormine and trandate). A reduction in intramyocardial tension has been stated to depend mainly on hemodynamic factors (reduction in volume or pressure overload on the myocardium) whereas the diminution of the myocardial mass also depends on neurohumoral effects.