Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Short-term tests and mycotoxins.

C Malaveille, H Bartsch

    Annales De La Nutrition Et De L'Alimentation
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Naturally occurring fungal toxins, like aflatoxins, are potent carcinogens in various species. Short-term tests help assess mycotoxin risks and understand their metabolic activation in mammals and humans.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The choice of controls in a case-control study on WBC-DNA adducts and metabolic polymorphisms.

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2013
    Same author

    Liver microsome-mediated mutagenicity of dihydrodiols derived from dibenz(a,c)anthracene in S. typhimurium TA100.

    Carcinogenesis·2012
    Same author

    DNA adduct formation and 7-ethoxyresorufin O-deethylase induction in primary culture of rainbow trout hepatocytes exposed to benzo[a]pyrene.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.

    Epigenetics·2009
    Same author

    Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?

    Cancer causes & control : CCC·2008
    Same author

    Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.

    Annals of oncology : official journal of the European Society for Medical Oncology·2007
    Same journal

    [Methods of fractionation of cellular structures].

    Annales de la nutrition et de l'alimentation·2014
    Same journal

    [Housing of cattle and milk production].

    Annales de la nutrition et de l'alimentation·2014
    Same journal

    [Chronic infections of the udder; their consequences on the production and composition of milk].

    Annales de la nutrition et de l'alimentation·2014
    Same journal

    [Prophylaxis and treatment of mastitis].

    Annales de la nutrition et de l'alimentation·2014
    Same journal

    [Venereal diseases and milk production].

    Annales de la nutrition et de l'alimentation·2014
    Same journal

    [Physiological disorders of lactation; abnormal physiological milk].

    Annales de la nutrition et de l'alimentation·2014
    See all related articles

    Area of Science:

    • Environmental Toxicology
    • Mycology
    • Carcinogenesis

    Background:

    • Naturally occurring fungal metabolites, such as aflatoxins and sterigmatocystin, are toxic and hepatocarcinogenic environmental contaminants.
    • These mycotoxins affect various species, including fish, birds, mammals, and potentially humans.
    • Their biological potency necessitates the search for other carcinogenic fungus-derived products.

    Purpose of the Study:

    • To review the predictive value of short-term tests for assessing mycotoxin carcinogenic risk.
    • To evaluate the utility of these tests in investigating the metabolic activation mechanisms of mycotoxins.
    • To present various short-term tests for detecting potential chemical carcinogens.

    Main Methods:

    • Utilizing short-term tests as screening techniques for compounds' genetic and carcinogenic potency.

    Related Experiment Videos

  • Employing endpoints such as mutagenesis, DNA repair, chromosomal aberrations, cell transformation, cytological alterations, and nucleic acid reactions.
  • Conducting in vivo and in vitro assays to detect potential chemical carcinogens.

    • Main Results:

    • Short-term tests demonstrate predictive value in assessing carcinogenic risk from mycotoxins.
    • These assays are useful for investigating the metabolic activation pathways of mycotoxins in mammals and humans.
    • Various short-term tests can effectively screen for potential carcinogens.

    Conclusions:

    • Short-term tests are valuable tools for evaluating the carcinogenic potential of mycotoxins.
    • Understanding metabolic activation is crucial for assessing human health risks associated with mycotoxins.
    • Continued research using these assays can identify and mitigate risks from environmental contaminants.