Related Experiment Video
Updated: Aug 4, 2026

A Novel Method of Drug Administration to Multiple Zebrafish (Danio rerio) and the Quantification of Withdrawal
Published on: November 12, 2014
Withdrawal after substitution of a short-acting for a long-acting benzodiazepine
Abstract:
A withdrawal syndrome occurred in two patients after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine. Both patients had used long-acting benzodiazepines on a daily basis for many years. In one case, oxazepam was substituted for diazepam, and in the other, temazepam was substituted for flurazepam hydrochloride. In both cases the short-acting benzodiazepine was substituted in a once-daily dosage. Withdrawal symptoms followed and persisted for at least one month. Relative advantages and disadvantages of short-acting and long-acting benzodiazepines are discussed.
More Related Videos
10:26Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
02:32An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality
Published on: March 29, 2024
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
CNS Depressants: Barbiturates and Benzodiazepines
Anxiolytic Drugs: Benzodiazepines and Buspirone
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Anthelminthic Agents