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Related Experiment Videos

Pregnancy and cystinuria.

M C Gregory, M A Mansell

    Lancet (London, England)
    |November 19, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Managing cystinuria during pregnancy with high fluid intake and D-penicillamine is safe. Most patients achieve normal births, with careful management minimizing risks for mother and fetus.

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    Area of Science:

    • Nephrology
    • Obstetrics
    • Medical Genetics

    Background:

    • Cystinuria is a rare genetic disorder.
    • It causes recurrent kidney stones.
    • Pregnancy in cystinuria patients requires careful management.

    Purpose of the Study:

    • To evaluate the safety and outcomes of managing cystinuria during pregnancy.
    • To assess the role of high fluid intake and D-penicillamine.

    Main Methods:

    • Retrospective analysis of 46 pregnancies in cystinuria patients.
    • Treatment included high fluid intake +/- D-penicillamine.
    • Outcomes monitored for maternal and fetal health.

    Main Results:

    • 41 normal births occurred.

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  • 18 new stones formed, with 4 passing spontaneously.
  • No surgical stone removal was needed during pregnancy.
  • Hypertension and UTIs were managed conventionally.

    • Conclusions:

    • High fluid intake is crucial during pregnancy and postpartum.
    • D-penicillamine is safe for severe cases but not always necessary.
    • Stone-forming cystinurics can have safe pregnancies with proper medical care.