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Kidney function in an unselected lithium population. A cross-sectional study.

H Bendz, S Andersch, M Aurell

    Acta Psychiatrica Scandinavica
    |November 1, 1983
    PubMed
    Summary
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    Robert Tigerstedt, scientist, teacher and critic.

    Svensk medicinhistorisk tidskrift·2002

    Lithium treatment can impair kidney function, particularly tubular function, even at non-toxic doses. Age negatively impacts glomerular filtration rate in patients undergoing lithium therapy.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Psychiatry

    Background:

    • Lithium is a widely prescribed mood stabilizer for bipolar disorder.
    • Long-term lithium use raises concerns regarding potential kidney toxicity.
    • Understanding lithium's impact on renal function is crucial for patient management.

    Purpose of the Study:

    • To assess kidney function in lithium outpatients.
    • To correlate renal function with demographic and treatment variables.
    • To differentiate effects on glomerular versus tubular kidney function.

    Main Methods:

    • Studied 124 lithium outpatients (short- and long-term).
    • Measured glomerular and distal tubular function.
    • Correlated renal function with age, lithium preparation type, and neuroleptic co-treatment.

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    Main Results:

    • Significant negative correlation between age and glomerular filtration rate (GFR).
    • Tubular function was impaired in 51% of patients; GFR was impaired in only 3%.
    • No significant differences in kidney function based on lithium preparation or neuroleptic co-treatment.

    Conclusions:

    • Non-toxic lithium doses affect kidney function, primarily tubular function.
    • Tubular function appears more susceptible to lithium than glomerular function.
    • Age is a significant factor affecting GFR in lithium-treated patients.