Epidemic hemorrhagic fever with renal syndrome. A broadening horizon

A virus identical to or closely related to the viruses of the epidemic hemorrhagic fevers and/or nephropathia epidemica has been demonstrated serologically in rats from geographically separate areas of this country by three groups of investigators. This information suggests a previously unrecognized health threat that should be considered in the differential diagnosis of patients initially seen with febrile illnesses and acute renal failure. The salient features of these viral diseases and the clues that should alert the clinician to seek serologic confirmation of Hantaan or an immunologically related virus are discussed herein.