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Clinical use of captopril in Takayasu's disease
Archives of Internal Medicine
|January 1, 1984
Insights
Captopril, an effective converting enzyme inhibitor, offers a conservative treatment option for Takayasu's disease (TD). This approach is recommended for patients with hypertension or heart failure when surgery is not feasible.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Takayasu's disease (TD) is a rare inflammatory condition affecting large arteries, often leading to renovascular hypertension and heart failure.
- Surgical interventions for renovascular hypertension in TD can be challenging due to the diffuse nature of the arteritis.
Abstract:
Three patients with Takayasu's disease (TD), initially observed with hypertension and/or congestive heart failure, were treated with captopril, an orally active inhibitor of converting enzyme. As arteritis in this disease is diffuse and extensive, surgical correction of renovascular hypertension is often delayed or impossible. Our experience enables us to recommend captopril for conservative treatment in TD.