Related Experiment Videos
Placental kappa binding site : interaction with dynorphin and its possible implication in hCG secretion
Life Sciences
|January 1, 1983
Summary
Human placenta possesses kappa opiate binding sites. Dynorphin
Area of Science:
- Reproductive biology
- Endocrinology
- Pharmacology
Background:
- Human placenta contains a homogenous population of kappa opiate binding sites.
- The endogenous opioid system may play a role in placental physiology.
Purpose of the Study:
- To investigate the physiological role of placental opiate receptors in human chorionic gonadotropin (hCG) secretion.
Main Methods:
- Selective interaction of dynorphin with placental kappa binding sites was observed.
- Ethylketocyclazocine was used to stimulate potassium-induced hCG release.
Main Results:
- Dynorphin selectively interacts with placental kappa opiate binding sites.
- Ethylketocyclazocine stimulates potassium-induced hCG release from the placenta.
Conclusions:
- The findings support the hypothesis that placental opiate receptors participate in the regulation of hCG secretion.
- This suggests a potential physiological role for the endogenous opioid system in placental function.