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[Ketoconazole-induced hepatitis. Case report].

H Henning, B Kasper, C J Lüders

    Zeitschrift Fur Gastroenterologie
    |December 1, 1983
    PubMed
    Summary
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    Ketoconazole, an antifungal drug, can cause rare but serious liver damage (hepatitis). Monitoring liver function tests is crucial during treatment to detect this side effect early.

    Area of Science:

    • Hepatology
    • Pharmacology
    • Toxicology

    Background:

    • Ketoconazole is a systemic antifungal agent effective for severe fungal infections.
    • Hepatotoxicity is a rare but significant adverse effect associated with Ketoconazole therapy.

    Observation:

    • This case study highlights Ketoconazole-induced hepatitis, which can mimic viral hepatitis (e.g., Non-A-Non-B).
    • A drug challenge with Ketoconazole led to a marked increase in serum enzymes including GOT, GPT, and GLDH.

    Findings:

    • Histological examination revealed toxic hydropic changes in hepatocytes and inflammatory infiltration.
    • Serum enzyme levels normalized approximately 12 weeks after discontinuing the drug.

    Implications:

    • Clinicians should consider drug-induced liver injury in patients presenting with hepatitis symptoms.

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  • Regular liver function monitoring is recommended 2-3 weeks after initiating Ketoconazole therapy and monthly thereafter.