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[Chronic analgesic-induced headache].

J Dichgans, H C Diener, W D Gerber

    Deutsche Medizinische Wochenschrift (1946)
    |March 9, 1984
    PubMed
    Summary
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    Regular analgesic use, particularly mixed-type drugs, can induce chronic headaches. Discontinuing these medications significantly improves headache symptoms and reduces reliance on pain relievers.

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Investigated the link between regular analgesic use and chronic headaches in patients with a history of migraine, vasomotor, or post-contusional headaches.
    • Assessed patients with long-standing daily headaches, averaging 7.6 years, with many experiencing migraine for over 21 years.

    Observation:

    • Patients regularly consumed mixed-type analgesics, averaging 35.6 tablets weekly, and had used over three different drugs.
    • A hospital stay was initiated to abruptly discontinue all analgesics, monitoring withdrawal symptoms including headache exacerbation, nausea, vomiting, and neurological episodes.

    Findings:

    • Complete headache resolution or marked improvement occurred in 77% of patients post-discontinuation.
    • Sustained improvement was observed in 70% of patients at 16-month follow-up.

    Related Experiment Videos

  • Significant reductions in headache frequency and intensity were noted, especially in patients with pre-existing migraine.

    • Implications:

    • Regular intake of mixed-type analgesics, including ergotamine tartrate and aminophenol derivatives, can induce chronic headaches.
    • Barbiturates, caffeine, and codeine contribute to the initiation and maintenance of dependence on anti-migraine medications.
    • Abrupt cessation of analgesics in a controlled setting can effectively treat medication-induced chronic headaches.