The regulation of cardiovascular functions by monoamine neurotransmitters in the brain

The complexity of the central nervous system's influence on cardiovascular integration is underscored by the extensive neural interconnections between the various higher and lower brain structures shown by electrophysiological studies to have an influence on cardiovascular function. Furthermore, complex neural connections exist within each level of cardiovascular integration (for instance, the medullary reticular formation, or the limbic system). The electrophysiological analysis of the integrative aspects of central cardiovascular regulation has been the subject of several reviews (Reis, 1972; Smith, 1974; Calaresu et al., 1975; Oberg, 1976). In recent years, the methodology of analyzing the anatomical neural pathways of central cardiovascular regulation by lesion-degeneration, evoked potential, and fluorescent histochemical procedures, has been improved with the introduction of anterograde and retrograde tracer techniques. The result is the delineation of previously undetected neural interconnections among various brain areas, long known as cardiovascular centres, such as the NTS, the parabrachial nucleus, the paraventricular nucleus of the hypothalamus, the central nucleus of the amygdala, and the bed nucleus of the stria terminalis (Loewy & McKellar, 1980). Undoubtedly the next few years will see major advances in the understanding of the neuroanatomical pathways involved in central cardiovascular control.