Related Experiment Video
Updated: Aug 10, 2026

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties
Published on: November 3, 2008
The effects of pressure on the molecular structure and physiological functions of cell membranes
Abstract:
The effects of high pressure on the phase state and molecular structure of pure lipid bilayers are discussed. The relations of delta H, delta S and delta V in phase transitions are straightforward and are discernible in heterogeneous bilayers in natural membranes. The effects of pressure on the dynamic properties of bilayer constituents are less clearly understood, but order parameters obtained at pressure by different techniques show agreement. The extent and significance of hydration is poorly understood. Four physiological functions are discussed: passive permeability, active transport, membrane excitability and synaptic transmission. It is shown that a full interpretation of the kinetic effects of pressure on these processes requires much more detailed molecular information than is available at present.
Related Concept Videos
What are Membranes?
Membrane Fluidity
Osmosis and Osmotic Pressure of Solutions
What are Membranes?
Membrane Fluidity
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Mechanisms of Membrane-bending
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...

