Effect of dose on increased etonitazene self-administration by rats due to food deprivation

Rats were trained to self-administer IV-delivered etonitazene while food satiated. A wide range of etonitazene doses (5-80 micrograms/kg) and saline were tested under food satiation and food deprivation conditions. Food deprivation produced a parallel increase in the dose-response function under FR 1 and FR 16 schedule conditions.