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Epidermal growth factor immunoreactive material in the central nervous system: location and development
Science (New York, N.Y.)
|June 8, 1984
Summary
Epidermal growth factor (EGF) was found in the rat brain, particularly in areas controlling movement. This suggests EGF may act as a neurotransmitter or neuromodulator in the central nervous system.
Area of Science:
- Neuroscience
- Endocrinology
- Gastroenterology
Background:
- Epidermal growth factor (EGF) is recognized for its role as a mitogen and its hormonal functions within the gastrointestinal tract.
- The presence and function of EGF in the central nervous system (CNS) are not fully understood.
Purpose of the Study:
- To investigate the presence and localization of Epidermal Growth Factor (EGF) in the central nervous system of the albino rat.
- To explore the potential role of EGF as a gut-brain peptide with neurotransmitter or neuromodulator functions.
Main Methods:
- Indirect immunofluorescence technique was employed to detect EGF-cross-reacting material.
- Analysis focused on the developing and adult albino rat brain.
Main Results:
- EGF-cross-reacting material was detected in various central nervous system structures of the rat.
- High concentrations were observed in specific pallidal areas, including the globus pallidus, ventral pallidum, entopeduncular nucleus, substantia nigra pars reticulata, and islands of Calleja.
Conclusions:
- The findings indicate that EGF is present in key brain regions associated with motor control.
- EGF may function as a gut-brain peptide, potentially exerting neurotransmitter or neuromodulator effects in the pallidal structures of the extrapyramidal motor system.