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Updated: Aug 16, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Sulfasalazine hepatotoxicity
Abstract:
Hepatotoxicity has been recently described as a rare complication of sulfasalazine therapy. Two patients with hepatic damage after sulfasalazine treatment are reported. Liver biopsy performed in one patient revealed granulomatous hepatitis. On rechallenge with 5 aminosalicylic acid enema the second patient developed a hypersensitivity reaction without hepatic involvement.
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