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Genetic aspects of multiple endocrine neoplasia

R N Schimke

    Annual Review of Medicine
    |January 1, 1984
    PubMed

    Insights

    Multiple endocrine neoplasia (MEN) syndromes are inherited autosomal dominant disorders. While three MEN syndromes are known, the underlying genetic defects for these and potential additional entities remain unclear.

    Area of Science:

    • Endocrinology
    • Genetics
    • Hereditary diseases

    Background:

    • Multiple endocrine neoplasia (MEN) syndromes are a group of inherited endocrine disorders.
    • Currently, three distinct MEN syndromes are well-characterized.
    • These syndromes follow an autosomal dominant inheritance pattern.

    Purpose of the Study:

    • To summarize the current understanding of multiple endocrine neoplasia syndromes.
    • To highlight the known genetic inheritance patterns.
    • To underscore the ongoing mystery surrounding the specific genetic defects.

    Main Methods:

    • Review of existing scientific literature on multiple endocrine neoplasia.
    • Analysis of established genetic inheritance models for MEN syndromes.
    • Synthesis of current knowledge regarding genetic defects.

    Main Results:

    • Three distinct multiple endocrine neoplasia syndromes have been identified.
    • All known MEN syndromes are inherited as autosomal dominant traits.
    • Evidence suggests the existence of additional, yet unidentified, MEN entities.

    Conclusions:

    • The genetic basis of multiple endocrine neoplasia syndromes requires further elucidation.
    • Despite significant research, the precise genetic defect causing MEN remains unknown.
    • Continued investigation is necessary to identify all MEN syndromes and their causative genetic mutations.

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