Neuroendocrine mechanisms mediating fluid intake during the estrous cycle

Gonadal steroids appear to influence fluid-electrolyte homeostasis through behavioral as well as renal mechanisms. The marked fluctuations in drinking behavior observed during the estrous cycle of the female rat may be due to an interaction between estrogen and the dipsogenic peptide hormone, angiotensin II, at the level of basal forebrain receptors. The preoptic region in particular may play an important integrative role in the maintenance of extracellular fluid balance in synchrony with the estrous cycle, since it contains receptors for angiotensin and estrogen. Prolactin may also directly participate in mechanisms of extracellular thirst, while an exact role for vasopressin has yet to be established. Recent studies also suggest that estrogens may influence body fluid regulation by interacting with several neurotransmitters, including serotonin, dopamine and noradrenaline.