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Related Experiment Videos

Transfusion of circulating stem cells.

D M McCarthy, J M Goldman

    Critical Reviews in Clinical Laboratory Sciences
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Pluripotential stem cells in bone marrow can restore blood formation. Research suggests these stem cells may also circulate in blood, potentially aiding in treatments for certain leukemias.

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    Area of Science:

    • Hematology
    • Stem Cell Biology
    • Oncology

    Background:

    • Bone marrow contains pluripotential stem cells crucial for hemopoiesis.
    • The presence and function of circulating pluripotential stem cells across species remain under investigation.

    Purpose of the Study:

    • To explore the presence and potential therapeutic value of circulating pluripotential stem cells.
    • To investigate the feasibility of using circulating stem cells for bone marrow reconstitution.

    Main Methods:

    • Review of studies on hemopoietic reconstitution using peripheral blood cells in various species (mice, dogs, baboons).
    • Analysis of experiments involving fresh and cryopreserved blood mononuclear cells in dogs.
    • Examination of in vitro culture data for circulating myeloid progenitor cells in humans.

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  • Observation of pluripotential stem cell numbers in chronic granulocytic leukemia patients.

    • Main Results:

    • Hemopoietic reconstitution achieved with peripheral blood cells in mice, dogs, and potentially baboons.
    • A dose-response relationship identified for mononuclear cells in dogs, predicting reconstitution success.
    • Anecdotal evidence in humans suggests potential, but not definitive, value of circulating stem cells.
    • Elevated circulating pluripotential stem cells observed in chronic granulocytic leukemia, enabling autograft potential.

    Conclusions:

    • Circulating pluripotential stem cells show promise for hemopoietic reconstitution, particularly in certain animal models and specific human leukemias.
    • Further research is needed to establish the definitive role and clinical utility of circulating stem cells in various human diseases and neoplasms.