Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphic behaviour of chloroquine diphosphate.

P Van Aerde, J P Remon, D De Rudder

    The Journal of Pharmacy and Pharmacology
    |March 1, 1984
    PubMed
    Summary

    Investigating chloroquine diphosphate revealed two polymorphic forms. Differences were detected by thermal analysis but not spectral analysis, indicating a transition phase phenomenon.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vertebroplacental ratio for prediction of perinatal outcome and operative delivery for suspected fetal compromise: prospective observational cohort study.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
    Same author

    Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO extrudates.

    International journal of pharmaceutics·2023
    Same author

    Pharmaceutical compounding of orphan active ingredients in Belgium: how community and hospital pharmacists can address the needs of patients with rare diseases.

    Orphanet journal of rare diseases·2019
    Same author

    Downscaling of the tableting process: Feasibility of miniaturized forced feeders on a high-speed rotary tablet press.

    International journal of pharmaceutics·2018
    Same author

    Impact of blend properties on die filling during tableting.

    International journal of pharmaceutics·2018
    Same author

    Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press.

    International journal of pharmaceutics·2018

    Area of Science:

    • Pharmaceutical Chemistry
    • Solid-State Chemistry
    • Materials Science

    Background:

    • Chloroquine diphosphate is an important antimalarial drug.
    • Understanding its solid-state properties, including polymorphism, is crucial for formulation and stability.
    • Polymorphism can significantly impact drug bioavailability and efficacy.

    Purpose of the Study:

    • To investigate the crystalline structure and polymorphism of chloroquine diphosphate.
    • To identify and characterize different polymorphic modifications.
    • To understand the factors influencing polymorphic transitions.

    Main Methods:

    • Differential Thermal Analysis (DTA) was used to study thermal behavior.
    • Spectral analysis (e.g., IR, Raman, NMR - specific type not mentioned in abstract) was employed for structural comparison.
    • Recrystallization studies were performed, including the use of seed material.

    Main Results:

    • Two distinct polymorphic modifications were identified in one batch of chloroquine diphosphate using DTA.
    • Spectral analysis did not reveal structural differences between the observed forms.
    • The second modification appears to form during the transition phase detected by DTA, suggesting a kinetic phenomenon.
    • Recrystallization can be initiated by seed material.
    • The ratio of transition heat between polymorphic forms is influenced by particle size and heating rate during DTA.

    Conclusions:

    • Chloroquine diphosphate exhibits polymorphism, with at least two detectable forms.
    • DTA is sensitive to polymorphic transitions that may not be evident through standard spectral analysis.
    • The formation of a second polymorph is likely a transition phase phenomenon, influenced by experimental conditions like seeding, particle size, and heating rate.

    Related Experiment Videos