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Related Experiment Videos

Xylan--a possible filler and disintegrant for tablets.

M Juslin, P Paronen

    The Journal of Pharmacy and Pharmacology
    |April 1, 1984
    PubMed
    Summary

    Xylan, a novel tablet adjuvant, was compared to modified starch. Xylan-containing tablets showed improved strength and faster disintegration without affecting weight variation, suggesting its potential in tablet formulation.

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    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Tablet formulation relies on excipients for desired physical and disintegration properties.
    • Modified starch (Sta-Rx 1500) is a commonly used tablet binder and disintegrant.
    • Novel excipients are continuously explored to enhance tablet performance.

    Purpose of the Study:

    • To evaluate xylan as a potential tablet adjuvant.
    • To compare the performance of xylan with modified starch (Sta-Rx 1500) in tablet formulations.
    • To assess the impact of xylan on tablet weight variation, strength, and disintegration time.

    Main Methods:

    • Tablets were prepared using xylan and modified starch as adjuvants.
    • Comparative analysis of tablet weight variation was conducted.
    • Tablet mechanical strength (e.g., crushing strength) was measured.
    • Tablet disintegration times were recorded under standard conditions.

    Main Results:

    • No significant differences in weight variation were observed between tablets formulated with xylan and modified starch.
    • Tablets containing xylan exhibited superior mechanical strength compared to those with modified starch.
    • Xylan significantly accelerated the disintegration rate of tablets in comparison to modified starch.

    Conclusions:

    • Xylan demonstrates promising adjuvant properties for tablet manufacturing.
    • Xylan offers advantages over modified starch in terms of tablet strength and disintegration.
    • Xylan is a viable alternative excipient for improving tablet quality attributes.

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