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Related Experiment Videos

Theophylline reassessed.

M Bukowskyj, K Nakatsu, P W Munt

    Annals of Internal Medicine
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This review details recent advances in theophylline pharmacokinetics, highlighting its role in reactive airways disease therapy. It covers drug interactions, clearance factors, and new therapeutic actions, emphasizing sustained-release formulations.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy

    Background:

    • Theophylline remains a key therapeutic agent for reactive airways disease.
    • Understanding its pharmacokinetics is crucial for optimizing treatment.
    • Recent research has expanded knowledge of theophylline's actions and interactions.

    Purpose of the Study:

    • To correlate updated pharmacokinetic data with theophylline's current therapeutic applications.
    • To review recent investigations (last 5 years) on theophylline's mechanisms, clearance, and clinical use.

    Main Methods:

    • Critical review of scientific literature published within the last five years.
    • Analysis of data concerning theophylline's pharmacokinetics, pharmacodynamics, and clinical efficacy.

    Main Results:

    Related Experiment Videos

    • Theophylline clearance is reduced by erythromycin, cimetidine, high-dose allopurinol, oral contraceptives, and caffeine.
    • Phenobarbital and phenytoin increase theophylline clearance.
    • New actions include improved diaphragmatic contractility, enhanced ventilatory response to hypoxia, and potential sleep disturbances.

    Conclusions:

    • Theophylline's role in reactive airways disease is supported by new pharmacokinetic insights.
    • Factors affecting clearance and newly identified actions are clinically relevant for daily use.
    • Sustained-release theophylline preparations are important for managing this medication effectively.