Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in transmitter output and synaptic ultrastructure at lobster neuromuscular terminals with decentralization.

R G Chiang, C K Govind

    Brain Research
    |May 14, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fiber composition of the distal accessory flexor muscle in several decapod crustaceans.

    Journal of morphology·2018
    Same author

    Vascularization of a lobster muscle.

    Journal of morphology·2018
    Same author

    Morphology of neurosecretory cells delineated with cobalt applied extracellularly to the cephalic aorta of the insect Rhodnius prolixus.

    Journal of morphology·2018
    Same author

    Composition of external setae during regeneration and transformation of the bilaterally asymmetric claws of the snapping shrimp, Alpheus heterochelis.

    Journal of morphology·2018
    Same author

    DEVELOPMENT OF THE DIMORPHIC CLAW CLOSER MUSCLES OF THE LOBSTER HOMARUS AMERICANUS. III. TRANSFORMATION TO DIMORPHIC MUSCLES IN JUVENILES.

    The Biological bulletin·2018
    Same author

    Retarded and Mosaic Phenotype in Regenerated Claw Closer Muscles of Juvenile Lobsters.

    The Biological bulletin·2018
    Same journal

    IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

    Brain research·2026
    Same journal

    Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

    Brain research·2026
    Same journal

    Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

    Brain research·2026
    Same journal

    Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

    Brain research·2026
    Same journal

    Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

    Brain research·2026
    Same journal

    Emotions, the amygdala, and the right hemisphere.

    Brain research·2026
    See all related articles

    Decentralization of lobster neuromuscular terminals reduced transmitter release and synaptic function. Structural changes, including fewer presynaptic dense bars and smaller synapses, correlated with the severity of this functional decline.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Marine Biology

    Background:

    • Neuromuscular junctions are critical for muscle function.
    • Decentralization, or loss of central nervous system control, can impact neuronal function.
    • Lobster neuromuscular systems provide a model for studying synaptic plasticity.

    Purpose of the Study:

    • To investigate the physiological and ultrastructural effects of decentralization on lobster neuromuscular terminals.
    • To quantify changes in synaptic transmission and identify structural alterations.

    Main Methods:

    • Transection of the excitor axon to the distal accessory flexor muscle in lobsters (Homarus americanus).
    • Recording of excitatory junctional potentials and synaptic currents.
    • Serial section electron microscopy of neuromuscular terminals.

    Related Experiment Videos

    Main Results:

    • Decentralization reduced excitatory junctional potential amplitude, indicating decreased transmitter release.
    • Synaptic current recordings confirmed reduced transmission and decreased mean quantal content (2-7 fold).
    • Ultrastructural analysis revealed progressive loss of presynaptic dense bars, synapses, and terminal size with increasing severity of decentralization.

    Conclusions:

    • Decentralization leads to a progressive loss of structural parameters controlling transmitter release at neuromuscular terminals.
    • Synaptic vesicles and mitochondria showed no significant changes.
    • These findings elucidate the relationship between structural integrity and synaptic function under decentralized conditions.