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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

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Mutagenicity in gastric juice.

D L Morris, D Youngs, T J Muscroft

|July 1, 1984

Summary

Gastric ulcer, carcinoma, and post-gastric resection patients showed increased gastric juice mutagenicity. This mutagenicity correlated with higher gastric pH and bacterial counts, not histidine levels.

Area of Science:

Gastroenterology
Microbiology
Oncology

Background:

Mutagenicity in gastric juice is a potential risk factor for gastric diseases.
Previous studies have explored various factors influencing gastric mutagenicity.

Purpose of the Study:

To investigate mutagenicity levels in gastric juice across different patient groups.
To identify factors correlating with elevated gastric mutagenicity.

Main Methods:

Employed the Ames bacteriological test system to assess mutagenicity in gastric juice samples.
Analyzed samples from 228 patients, including controls, duodenal ulcer, gastric ulcer, carcinoma, and post-gastric resection groups.
Correlated mutagenicity with gastric juice pH, bacterial count, and histidine concentration.

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Main Results:

Significantly increased mutagenicity was observed in patients with gastric ulcer (p < 0.002), carcinoma (p < 0.002), and after gastric resection (p < 0.01) compared to controls.
A transient increase in mutagenicity was noted after H2 antagonist ingestion (p < 0.002).
Mutagenicity levels strongly correlated with gastric juice pH and bacterial count.

Conclusions:

Gastric juice mutagenicity is elevated in specific gastrointestinal conditions, including gastric ulcer, carcinoma, and post-gastric resection.
Gastric pH and bacterial load are key determinants of gastric mutagenicity.
Histidine levels do not appear to explain the observed mutagenicity.