Behavior of ATP toward phenothiazine drugs

The tricyclic amines promazine, promethazine, chlorpromazine, triflupromazine, and trifluperazine form solid ion pairs with ATP in a 1:2 molar ratio. There is a good correlation between the measured Ksp and the apparent diffusion constants of the ion pairs with the critical micelle concentration (CMC) of the corresponding phenothiazines. Solid ion pairs are solubilized by phenothiazine micelles; the binding constants of ATP to drug micelles are calculated from solubility data at 25 degrees C and can be related to the CMC of the phenothiazines.