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Naloxone reserves the inhibitory effects of dynorphin A on motor activity in the mouse
Pharmacology, Biochemistry, and Behavior
|May 1, 1984
Abstract:
Dynorphin-(1-17) (dynorphin A) significantly reduced the linear locomotion, rearing and grooming behaviors in mice using a newly devised multi-dimensional behavioral analyser. The behaviors inhibited by dynorphin A were dose-dependently antagonized by prior treatment with naloxone. The results suggest that dynorphin A-induced behavioral depression is mediated via opioid receptors in the mouse brain.