Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Daytime sleepiness and antihistamines.

T A Roehrs, E I Tietz, F J Zorick

    Sleep
    |January 1, 1984
    PubMed
    Summary

    Diphenhydramine causes daytime sleepiness, unlike terfenadine. Sleepiness increased throughout the day, with subjects becoming progressively more alert despite antihistamine use.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    24&#x2003;Evaluation of an antibody-free approach to identifying faecal peptides for pregnancy detection in polar bears (<i>Ursus maritimus</i>).

    Reproduction, fertility, and development·2022
    Same author

    Materials Imaging and Dynamics (MID) instrument at the European X-ray Free-Electron Laser Facility.

    Journal of synchrotron radiation·2021
    Same author

    Efficacy of piperacillin in combination with novel β-lactamase inhibitor IID572 against β-lactamase-producing strains of Enterobacteriaceae and Staphylococcus aureus in murine neutropenic thigh infection models.

    The Journal of antimicrobial chemotherapy·2020
    Same author

    Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

    The Journal of antimicrobial chemotherapy·2018
    Same author

    Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

    The Journal of antimicrobial chemotherapy·2018
    Same author

    How representative are insomnia clinical trials?

    Sleep medicine·2018

    Area of Science:

    • Pharmacology
    • Sleep Medicine
    • Clinical Research

    Background:

    • Antihistamines are commonly used for allergies.
    • Some antihistamines cause drowsiness, impacting daily activities.
    • Understanding the hypnotic potential and daytime sleepiness is crucial.

    Purpose of the Study:

    • To evaluate daytime sleepiness induced by antihistamines.
    • To assess the hypnotic potential of specific antihistamines.
    • To compare diphenhydramine and terfenadine's effects on sleep.

    Main Methods:

    • A daytime nap procedure was employed in healthy subjects.
    • Participants received diphenhydramine (150 mg), terfenadine (120 mg), or placebo.
    • Sleep recordings were conducted across four nap opportunities throughout the day.

    Main Results:

    • Latency to stage 1 sleep significantly increased across naps, indicating rising alertness.
    • Diphenhydramine significantly shortened sleep latency compared to terfenadine and placebo.
    • No significant differences were observed in the amount of non-stage 1 sleep across drug conditions.

    Conclusions:

    • Diphenhydramine at 150 mg induces daytime sleepiness but has limited hypnotic potential.
    • Accumulated wakefulness throughout the day leads to increased alertness.
    • Individual antihistamine effects on sleepiness and hypnotic potential vary.

    Related Experiment Videos