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The hormonal changes produced by duodenogastric reflux
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1984
Summary
Duodenogastric reflux in dogs alters gut hormone levels. Gastric inhibitory peptide (GIP) significantly increased, while somatostatin levels decreased, impacting gastrointestinal function.
Area of Science:
- Gastroenterology
- Endocrinology
- Surgical Research
Background:
- Duodenogastric reflux (DGR) is a condition where bile and intestinal contents flow back into the stomach.
- The impact of DGR on key gastrointestinal hormones is not fully understood.
Purpose of the Study:
- To investigate the effects of surgically induced DGR on serum levels of various gastrointestinal hormones in a canine model.
- To compare hormone levels in systemic and portal venous blood.
Main Methods:
- Surgically created DGR in dogs.
- Measurement of serum levels of secretin, vasoactive intestinal polypeptide (VIP), gastric inhibitory peptide (GIP), somatostatin, insulin, and pancreatic polypeptide (PP).
- Analysis of hormones in both systemic and portal venous blood.
Main Results:
- Serum levels of secretin, VIP, insulin, and PP remained unchanged with DGR.
- Gastric inhibitory peptide (GIP) levels were significantly elevated in dogs with DGR.
- Somatostatin levels were significantly suppressed in dogs with DGR.
Conclusions:
- Surgically induced duodenogastric reflux in dogs significantly alters specific gut hormone profiles.
- Elevated GIP and suppressed somatostatin suggest a role for these hormones in the pathophysiology of DGR.