Related Experiment Video
Updated: Sep 23, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
The hormonal changes produced by duodenogastric reflux
Abstract:
Serum systemic and portal venous blood levels of secretin, vasoactive intestinal polypeptide (VIP), gastric inhibitory peptide (GIP), somatostatin, insulin and pancreatic polypeptide (PP) have been examined in dogs with and without surgically produced duodenogastric reflux. Serum levels of secretin, VIP, insulin and PP showed no change, but reflux caused a significant elevation of GIP levels and a suppression of somatostatin levels in both systemic and portal venous blood.
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