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Related Experiment Videos

Cyclic nucleotides in goats' milk: changes with physiological state.

D R Blatchford, A Faulkner, A J Henderson

    Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
    |January 1, 1984
    PubMed
    Summary

    Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels in goat milk change with physiological state. These cyclic nucleotides reflect changes in pregnancy, lactation, feeding, and milk secretion inhibition.

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    Area of Science:

    • Biochemistry
    • Animal Science
    • Reproductive Biology

    Background:

    • Cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are crucial intracellular messengers.
    • Their role in regulating physiological processes, including lactation, is of significant interest.
    • Understanding these roles can provide insights into mammary gland function and milk production.

    Purpose of the Study:

    • To investigate the dynamic changes in mammary secretion concentrations of cAMP and cGMP in goats.
    • To correlate these cyclic nucleotide levels with distinct physiological states of the mammary gland.
    • To elucidate the potential role of cAMP and cGMP in regulating milk secretion.

    Main Methods:

    • Quantification of cAMP and cGMP concentrations in mammary secretions collected from goats.

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  • Measurements were taken across various physiological conditions: late pregnancy, onset of lactation, late lactation, food withdrawal, re-feeding, and following colchicine-induced inhibition of milk secretion.

    • Main Results:

    • Both cAMP and cGMP concentrations increased during late pregnancy.
    • At the onset of copious milk secretion, cGMP decreased while cAMP further increased.
    • Following cessation of milking, cGMP levels rose, and cAMP levels tended to decrease.
    • Food withdrawal led to decreased milk secretion, increased cGMP, and decreased cAMP, with reversal upon re-feeding.
    • Colchicine treatment temporarily inhibited milk secretion, accompanied by increased cGMP and decreased cAMP.

    Conclusions:

    • Cyclic nucleotide concentrations in goat milk are sensitive indicators of the mammary gland's physiological state.
    • Changes in cAMP and cGMP levels correlate significantly with pregnancy, lactation, nutritional status, and milk secretion dynamics.
    • These findings suggest a regulatory role for cAMP and cGMP in controlling milk secretion processes in goats.