Extent of vaginal absorption of sulphated polysaccharide from A-gen 53 in the rabbit

The vaginal absorption of a sulphated polysaccharide (SAEP), the active substance of A-gen 53+, was studied in rabbits using the 35S-labelled product. After intra-vaginal administration of 35S-SAEP, measurements of 35S in urine, faeces, plasma and tissues of the reticulo-endothelial system indicated that the small proportion of the dose (ca. 5%) absorbed from the vagina was associated mainly with inorganic material (i.e. 35S-sulphate), present as an impurity in the 35S-dose.