Hepatocellular carcinoma with carcinoid features

A primary hepatic neoplasm with histologic features suggestive of both hepatocellular carcinoma and carcinoid tumor was studied by light microscopy, electron microscopy, and immunocytochemistry. These methods revealed areas of hepatocellular carcinoma, areas of carcinoid tumor, and mixed areas within the same cell. This case provides one more example of the coexistence of carcinoma and carcinoid in the same neoplasm and thereby supports the hypothesis that a malignantly transformed stem cell can differentiate in both epithelial and amine precursor uptake and decarboxylation (APUD) directions.