Related Experiment Video
Updated: Aug 11, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
Published on: September 1, 2015
Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy
Abstract:
Follicular labyrinthine foci, consisting of an association of retrovirus-like particles with expanded dendritic reticular ("antigen trapping") cells, are described in lymph nodes from four immunodeficient homosexual men with unexplained persistent lymphadenopathy. One patient has severe acquired immunodeficiency syndrome (AIDS) with complicating Pneumocystis carinii infection, and the others have AIDS-related lymphadenopathy syndrome. The findings support a role for routine electron microscopy as an aid to diagnostic evaluation of nodal tissue from patients with suspected AIDS. Viral non-lymphoid-cell tropism may be a significant factor in the pathogenesis of the disease.
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