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Updated: Aug 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Ketoconazole therapy for advanced prostate cancer
Abstract:
Fifteen patients with biopsy-proven prostate cancer were treated with ketoconazole 400 mg every 8 h. Two patients withdrew from therapy, one for personal reasons and one because a paraspinal mass developed. The other thirteen patients completed at least 6 months of therapy. Ketoconazole greatly reduced the need for analgesics; serum prostatic acid phosphatase levels fell to normal, and testosterone levels were reduced. After 6 months thirteen of fourteen evaluable patients were in remission. The side-effects of ketoconazole therapy were limited.
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