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Updated: Aug 7, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Ketoconazole therapy for advanced prostate cancer
Lancet (London, England)
|August 25, 1984
Summary
Ketoconazole effectively treated prostate cancer, reducing pain and lowering testosterone. Most patients achieved remission with limited side effects, showing promise for this treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Prostate cancer remains a significant health concern.
- Hormonal therapies are crucial for managing advanced prostate cancer.
Purpose of the Study:
- To evaluate the efficacy and tolerability of ketoconazole in treating prostate cancer.
Main Methods:
- Fifteen patients with biopsy-proven prostate cancer received ketoconazole (400 mg every 8 hours).
- Treatment duration was at least 6 months for most participants.
Main Results:
- Ketoconazole significantly reduced the need for analgesics.
- Serum prostatic acid phosphatase normalized, and testosterone levels decreased.
- Thirteen of fourteen evaluable patients achieved remission after 6 months.
Conclusions:
- Ketoconazole demonstrates significant efficacy in managing prostate cancer.
- The treatment was well-tolerated with minimal side effects.
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