Pharmacokinetic aspects of some behavioral effects of psychotropic drugs

We have studied the distribution of antidepressant agents, morphine and apomorphine, in rat blood and tissues and correlated the pharmacokinetic data with pharmacological responses induced by these drugs. We have found a direct relationship between apomorphine concentration in its effective compartment and pharmacological response, while morphine and antidepressants showed such relations only to some limited extents. Investigations of interaction between neuroleptics and apomorphine and morphine have revealed that some pharmacokinetic alterations are involved in neuroleptic-induced changes of pharmacological responses to both drugs. We have also found that the route of administration, dosage schedule, and satiation of animals may affect the distribution and metabolism of drugs, and this in turn may change their pharmacological effects.