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Behavioural correlates to the dopamine D-1 and D-2 antagonists
Polish Journal of Pharmacology and Pharmacy
|March 1, 1984
Summary
Neuroleptics, like thioxanthenes and phenothiazines, show varied behavioral effects and tolerance based on dopamine receptor blockade. This classification aligns with in vitro dopamine receptor binding techniques.
Area of Science:
- Neuropharmacology
- Behavioral Pharmacology
Background:
- Neuroleptics acutely block dopamine (DA) receptors, demonstrated by antagonizing DA-agonist-induced stereotypies in rodents.
- Several neuroleptic classes, including thioxanthenes, phenothiazines, butyrophenones, and benzamides, exhibit equipotent behavioral and clinical effects.
Purpose of the Study:
- To classify neuroleptics based on their behavioral effects and tolerance patterns.
- To compare in vivo behavioral classification with in vitro dopamine receptor binding data.
Main Methods:
- Neuroleptic antagonism of methylphenidate-induced stereotyped gnawing in mice.
- Assessment of neuroleptic effects following co-administration with scopolamine and diazepam.
- Evaluation of neuroleptic efficacy in mice rendered supersensitive by chronic treatment.
Main Results:
- Butyrophenone efficacy was attenuated by scopolamine and diazepam, while thioxanthenes and SCH 23390 were less affected.
- In supersensitive mice, thioxanthenes and SCH 23390 retained antagonism, phenothiazines showed reduced effects, and butyrophenones exhibited tolerance.
- Behavioral classification revealed three distinct neuroleptic groups.
Conclusions:
- Neuroleptics can be behaviorally classified into three groups based on their interaction with dopamine receptor blockade and tolerance development.
- This in vivo behavioral classification correlates with established in vitro dopamine receptor binding classifications.