Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Message transmission: receptor controlled adenylate cyclase system.

M Schramm, Z Selinger

    Science (New York, N.Y.)
    |September 21, 1984
    PubMed
    Summary

    The adenylate cyclase system, crucial for cell signaling, involves hormone receptors and GTP-binding proteins. Its activation and deactivation are tightly regulated through multiple mechanisms, including desensitization and inhibitory pathways.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    X-ray quasi-periodic eruptions from two previously quiescent galaxies.

    Nature·2021
    Same author

    [Pacemaker, defibrillator and co : Perioperative handling of cardiac implantable electronic devices].

    Der Anaesthesist·2017
    Same author

    [Histological Techniques].

    Klinische Monatsblatter fur Augenheilkunde·2016
    Same author

    [Pleural effusion cytology of asbestos-associated malignant mesothelioma and lung carcinoma in the diagnosis of occupational diseases by the statutory accident insurance funds].

    Pneumologie (Stuttgart, Germany)·2014
    Same author

    Characterization of the epidermis from barley primary leaves : I. Isolation of epidermal protoplasts.

    Planta·2013
    Same author

    Characterization of the epidermis from barley primary leaves : II. The role of the epidermis in ion compartmentation.

    Planta·2013

    Area of Science:

    • Biochemistry
    • Cellular Biology
    • Molecular Pharmacology

    Background:

    • The adenylate cyclase system mediates cellular responses to external stimuli.
    • This system comprises receptors, G-proteins, and catalytic units, translating signals into intracellular events.
    • Understanding its regulation is key to comprehending cellular communication.

    Purpose of the Study:

    • To elucidate the regulatory mechanisms of the adenylate cyclase system.
    • To detail the processes of activation and deactivation within this signaling pathway.
    • To identify unresolved questions regarding receptor-ligand interactions and G-protein signaling.

    Main Methods:

    • The study describes the components and interactions within the adenylate cyclase system.
    • It reviews known activation and deactivation processes.
    • It highlights areas requiring further investigation, such as receptor conformational changes and G-protein interactions.

    Main Results:

    • Receptor activation involves a tight binding ('locking') of the neurotransmitter.
    • Deactivation occurs via intrinsic GTPase activity of the Gs protein, receptor desensitization, and inhibitory G-proteins (Gi).
    • Specific conformational changes of receptors and broader G-protein interactions remain to be fully elucidated.

    Conclusions:

    • The adenylate cyclase system is a complex signaling network with multiple layers of regulation.
    • Further research is needed to fully characterize receptor dynamics and the diverse roles of G-proteins.
    • This intricate system is fundamental to various physiological processes.

    Related Experiment Videos