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Feeding systems in Chinese hamsters.

C J Billington, J E Morley, A S Levine

    The American Journal of Physiology
    |September 1, 1984
    PubMed
    Summary

    Chinese hamsters exhibit altered feeding behaviors, particularly when diabetic. Unlike rats, opiates and satiety peptides have minimal impact on their feeding, suggesting species-specific regulatory mechanisms.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Animal Behavior

    Background:

    • Chinese hamsters, particularly certain inbred strains, are susceptible to developing diabetes mellitus.
    • Diabetic Chinese hamsters exhibit hyperphagia (excessive eating) compared to nondiabetic controls.
    • Understanding feeding modulation is crucial for metabolic and neurological research.

    Purpose of the Study:

    • To investigate the role of opiates, satiety peptides, and dopamine in modulating feeding behavior in Chinese hamsters.
    • To compare feeding regulation mechanisms between Chinese hamsters and other species, such as rats.
    • To assess the impact of diabetes on feeding modulation in this species.

    Main Methods:

    • Administration of various neurochemicals including naloxone, butorphanol, N-allylnormetazocine, cholecystokinin, bombesin, somatostatin, pancreatic polypeptide, calcitonin, and haloperidol.
    • Measurement of feeding behavior in diabetic and nondiabetic Chinese hamsters.
    • Opiate receptor binding assays and measurement of immunoreactive dynorphin concentrations in brain tissue.
    • Assessment of hamster sensitivity to dopaminergic blockade.

    Main Results:

    • Naloxone and butorphanol did not affect feeding. Opiate receptor binding studies showed no specific binding for naloxone or ethylketocyclazocine.
    • N-allylnormetazocine (a sigma-opiate receptor agonist) stimulated feeding in diabetic hamsters.
    • Putative satiety peptides (cholecystokinin, bombesin, somatostatin, pancreatic polypeptide) were ineffective.
    • Calcitonin reduced feeding, potentially non-specifically. Dopaminergic blockade with haloperidol also limited feeding, with diabetic hamsters showing greater sensitivity.

    Conclusions:

    • Opiatergic and peptidergic influences on feeding in Chinese hamsters differ significantly from those observed in rats.
    • These pathways appear to play a limited role in regulating food intake in Chinese hamsters.
    • Dopaminergic systems and potentially calcitonin are involved in modulating feeding in this species, with diabetic hamsters exhibiting unique sensitivities.

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