High-dose neuroleptics for acute brain failure after intensive chemotherapy for acute leukemia

A 20-year-old Caucasian male with acute leukemia developed acute organic brain failure after treatment with intensive cytostatic chemotherapy. His delirious state was successfully controlled by neuroleptic therapy with intravenous haloperidol and lorazepam. We propose that this regimen may be useful in treating organic brain failure following intensive chemotherapy for malignant disease.