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Age-related changes in colonic function in rats.

J N McDougal, M S Miller, T F Burks

    The American Journal of Physiology
    |November 1, 1984
    PubMed
    Summary
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    Aging impairs gastrointestinal function in rats, decreasing colonic transit and muscle response. Senescent rats serve as a valuable model for studying age-related digestive changes.

    Area of Science:

    • Gastroenterology
    • Comparative Physiology
    • Gerontology

    Background:

    • Human aging is linked to altered gastrointestinal (GI) function.
    • Investigating age-related GI changes in animal models is crucial for understanding human aging.

    Purpose of the Study:

    • To determine if aging affects GI function in rats.
    • To assess the suitability of the senescent rat as a model for studying age-related GI changes.

    Main Methods:

    • Comparison of intestinal transit, colonic smooth muscle response (in vitro) to bethanechol and electrical stimulation, and colonic histology in postpubertal (5-12 mo) and senescent (25-28 mo) male Fischer 344 rats.
    • Quantification of colonic transit using 51Cr.
    • Measurement of muscle strip responses and EC50 for bethanechol.

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    Main Results:

    • Senescent rats exhibited a 45% decrease in colonic transit compared to younger rats.
    • Maximum muscle strip response to electrical stimulation was 32% lower in senescent rats.
    • Maximum muscle strip response to bethanechol was 16% lower in senescent rats, with no change in EC50.
    • No significant differences were observed in muscle layer thickness or percent circular muscle between age groups.

    Conclusions:

    • Aging significantly alters gastrointestinal motility and smooth muscle function in rats.
    • The senescent Fischer 344 rat is a suitable model for investigating age-related gastrointestinal changes.
    • Findings suggest potential mechanisms for age-related digestive dysfunction applicable to human studies.