Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vecuronium in renal failure.

D R Bevan, F Donati, H Gyasi

    Canadian Anaesthetists' Society Journal
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Vecuronium provides effective neuromuscular blockade in patients with end-stage renal failure, similar to normal patients. This muscle relaxant offers advantages like shorter action and easy reversal for renal failure patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Myocardial abscess: an unusual complication of long-term hemodialysis line presence.

    Clinical nephrology·1999
    Same author

    "One-stop" surgery: implications for anesthesiologists of an expedited pediatric surgical process.

    Southern medical journal·1999
    Same author

    Calculating the global burden of disease: time for a strategic reappraisal?

    Health economics·1999
    Same author

    Aerosol route enhances the contamination of intact eggs and muscle of experimentally infected laying hens by Salmonella typhimurium DT104.

    FEMS microbiology letters·1999
    Same author

    Short gastric artery perforation after use of 'ecstasy'.

    Journal of the Royal Society of Medicine·1999
    Same author

    Meniscal movement. An in-vivo study using dynamic MRI.

    The Journal of bone and joint surgery. British volume·1999

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Nephrology

    Background:

    • End-stage renal failure (ESRF) can alter drug pharmacokinetics.
    • Neuromuscular blocking agents require careful dosing in patients with renal impairment.

    Purpose of the Study:

    • To evaluate the dose-response and recovery characteristics of vecuronium in ESRF patients.
    • To compare vecuronium's effects in ESRF patients versus normal controls.

    Main Methods:

    • Administered vecuronium to 24 adult ESRF patients and 21 normal controls.
    • Constructed dose-response curves for 50%, 90%, and 95% neuromuscular blockade.
    • Assessed duration of action, cumulative effects, and recovery with neostigmine.

    Main Results:

    Related Experiment Videos

    • Effective doses for neuromuscular blockade were similar between ESRF and control groups.
    • Repeated vecuronium doses showed longer duration and some cumulation in ESRF patients.
    • Neostigmine rapidly and effectively reversed neuromuscular blockade in both groups without recurarization.

    Conclusions:

    • Vecuronium is effective for neuromuscular blockade in ESRF patients.
    • Vecuronium offers advantages of shorter duration and easy reversibility in renal failure.
    • Vecuronium may be a preferred neuromuscular blocking agent in patients with ESRF.