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Summary
Two patients developed amineptine (Survector) addiction, experiencing amphetamine-like symptoms after significantly increasing their dosage for atypical depression. This highlights the potential for psychological dependence and the need to re-evaluate this antidepressant's psychostimulant properties.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Pharmacology
Background:
- Amineptine (Survector) is an antidepressant prescribed for atypical depression, characterized by asthenia and activity deficits.
- Therapeutic doses (200 mg/day) were initially effective for apragmatism in two patients.
Observation:
- Both patients gradually escalated their amineptine intake to 2-3 g/day without apparent reason.
- Overconsumption led to symptoms including insomnia, hyperesthesia, irritability, dysarthria, anorexia, significant weight loss, and amphetamine-like effects.
Findings:
- Despite no physical dependence noted with clorazepate treatment, strong psychological dependence on amineptine was observed.
- These cases represent a rare instance of high-dose amineptine addiction with single-intake use.
Implications:
- The findings suggest a need to reassess amineptine's role among psychostimulant antidepressants.
- Further research into the addictive potential and risk management of amineptine is warranted.