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Does gastric acid release plasma somatostatin in man?
Gut
|November 1, 1984
Summary
Gastric acid infusion into the stomach does not affect plasma somatostatin levels. However, intraduodenal acid, at high doses, moderately stimulates somatostatin release, suggesting it
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Food intake and insulin-induced hypoglycemia increase somatostatin levels.
- Gastric acid secretion is stimulated by food and hypoglycemia.
- The direct effect of gastric acid on somatostatin secretion is unclear.
Purpose of the Study:
- To investigate the impact of gastric acid on plasma somatostatin concentrations in humans.
- To determine if gastric acid directly influences somatostatin release.
Main Methods:
- Healthy subjects received infusions of hydrochloric acid (HCl) into the stomach and duodenum.
- Plasma somatostatin levels were measured before and after HCl infusions.
- Different doses and durations of HCl infusion were employed.
Main Results:
- Intragastric HCl administration (15 mmol) did not alter plasma somatostatin.
- Small duodenal HCl infusion (4 mmol) had no effect on somatostatin.
- A large intraduodenal HCl infusion (60 mmol) over 30 minutes moderately increased plasma somatostatin.
- The peak somatostatin increase occurred at 10 minutes post-infusion.
Conclusions:
- Intragastric acid infusion does not stimulate circulating somatostatin in humans.
- Intraduodenal acidification, even at supraphysiological doses, is a moderate stimulus for somatostatin release.
- Gastric acid is unlikely to be a primary mediator of postprandial somatostatin release.
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