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Related Experiment Videos

H2-receptor blockade and exercise-induced asthma.

S G Nogrady, A G Hahn

    British Journal of Clinical Pharmacology
    |November 1, 1984
    PubMed
    Summary

    Cimetidine, an H2-receptor antagonist, did not affect lung function or exercise-induced bronchoconstriction in asthmatic individuals. This study found no significant differences in forced expiratory volume in one second (FEV1) after cold air exercise challenges.

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    Area of Science:

    • Pulmonary Medicine
    • Pharmacology
    • Allergy and Immunology

    Background:

    • In vitro studies suggest H2-receptor blockade may worsen asthma by increasing mediator release from mast cells.
    • However, in vivo human studies on the effects of H2-receptor antagonists on exercise-induced bronchoconstriction have yielded conflicting results.

    Purpose of the Study:

    • To investigate the in vivo effects of cimetidine on lung function and bronchial response to cold air exercise challenge in asthmatic subjects.

    Main Methods:

    • Eight asthmatic subjects participated in a double-blind, placebo-controlled study.
    • Subjects received either cimetidine (800 mg) or a placebo on separate days.
    • Lung function (FEV1) was measured before and at several time points after a standardized 8-minute cold air exercise challenge.

    Main Results:

    • No significant differences were observed in baseline FEV1 between cimetidine and placebo conditions.
    • Immediate post-exercise FEV1 and maximum percentage fall from baseline were similar on both treatment days.
    • Cimetidine did not alter bronchial responses to the cold air exercise challenge.

    Conclusions:

    • Cimetidine administration does not appear to significantly impact lung function or the bronchial response to cold air-induced exercise in individuals with asthma.
    • These in vivo findings do not support the hypothesis that H2-receptor blockade exacerbates exercise-induced bronchoconstriction in asthmatics.

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